Stanniocalcin-1 in medium sized arterial tissue
Research type
Research Study
Full title
Stanniocalcin-1 in medium sized arterial tissue
IRAS ID
351104
Contact name
Debasish Banerjee
Contact email
Sponsor organisation
City St George's University Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 8 months, 1 days
Research summary
Kidney patients suffer from high rates of death, often premature; and hospital admissions which are commonly related to heart problems, such as heart failure or heart attacks. In addition, a proportion of kidney patients progress to end stage kidney failure which results in more hospital admissions and deaths.
Even after using the available medicines there remains a high risk of heart disease and kidney failure in the 7.2 million people living with kidney disease in UK. Hence exploring pathways which will lead to new medicines to prevent future heart problems and kidney failure is very important.
The proposed study aims to explore a novel molecule called stanniocalcin-1 (STC-1). STC-1, is made by different tissues including the human kidney, heart, blood vessels and female reproductive system during both health and disease. It is reported to protect cells against inflammation and damaging signals in kidney disease.
We will recruit participants, both donors and recipients, who are going to undergo an elective kidney transplant operation. We will take a sample of their blood. We will also use tissue normally discarded as part of kidney transplant operation from both the recipient (kidney disease patient) and the donor (healthy individual) to look where STC-1is made in the blood vessel. We will then keep the blood vessel from the recipient in the donor blood and vice versa for 2 hours. This would help us find out whether there is something within the blood that causes the blood vessel to make STC-1.
This would give us more information on whether STC-1 is made by blood vessels and whether kidney disease causes more STC-1 to be made.REC name
West of Scotland REC 4
REC reference
24/WS/0171
Date of REC Opinion
17 Feb 2025
REC opinion
Further Information Favourable Opinion